Protective role of Proanthocyanidin in experimental ovarian torsion

نویسندگان

  • Adem Küçük Department of Pediatric Surgery, Düzce Atatürk State Hospital, Düzce, Turkey.
  • Ahmet Yıldırım Department of Emergency Medicine, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
  • Havva Erdem Department of Pathology, Düzce University Medical Faculty, Düzce, Turkey.
  • Mesut Erbaş Department of Anesthesiology, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
  • Mustafa Tekin Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
  • Naci Topaloğlu Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
  • Şule Yıldırım Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
چکیده مقاله:

  Background: Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury.   Methods : Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19.   Results : Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p< 0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation.   Conclusion : Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

protective role of proanthocyanidin in experimental ovarian torsion

background: proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ros) scavenger. the aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury.   methods : twenty four rats were randomly divided into three groups (n=8). group 1: the laparotomy group, group 2: ovarian torsion ...

متن کامل

Protective role of grape seed proanthocyanidin antioxidant properties on heart of streptozotocin-induced diabetic rats

Grape seed proanthocyanidin (GSP) bears a very powerful antioxidant effects. Studies demonstrated that proanthocyanidins protect against free radicals mediated cardiovascular and renal disorders. The present study was designed to assess the effect of GSP on the heart of diabetic rats. Forty rats were divided into four groups of 10 animals each: Group I: control, Group II: control group were giv...

متن کامل

Ovarian Torsion in Postmenopausal Women and risk of malignancy

Background & aim: Ovarian torsion is one of the most common causes of emergency surgery in gynecology, with a tendency to occur in postmenopausal women. The aim of this study was to provide information concerning the clinical presentations, surgical management, pathological findings and risk of malignancy in postmenopausal women with ovarian torsion. Methods:In this cross-sectional study, the r...

متن کامل

Protective effect of proanthocyanidin against oxidative ovarian damage induced by 3-nitropropionic acid in mice.

Oxidative stress, which poses a threat to reproductive health, causes many serious female reproductive diseases. In this study, we investigated whether proanthocyanidins (PC) have a protective effect against oxidative stress-induced ovarian damage. Forty female ICR mice were randomized into 4 groups: a control group, a control plus PC group, a 3-nitropropionic acid (3-NPA) group, and a 3-NPA pl...

متن کامل

Neonatal ovarian cysts: role of sonography in diagnosing torsion.

INTRODUCTION The purpose of this case series was to determine the sonographic features of neonatal ovarian torsion. MATERIALS AND METHODS Seven surgically proven cases of neonatal ovarian cysts were included in this retrospective study. The patients were divided into 2 groups, torsion and non-torsion. These 7 patients were evaluated for the clinical presentation, sonographic features, surgica...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 29  شماره 1

صفحات  210- 215

تاریخ انتشار 2015-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023